Do Age-related Epiphyseal Bone Differences in Osteoarthritic STR/Ort versus Healthy Mouse Tibias Reveal Future Early Imaging Biomarkers?

Description

This VTT (Web Video Text Tracks) file appears to document a scientific presentation discussing research on osteoarthritis using different mouse models, specifically STR/Ort mice and CBA mice. Lucinda Evans, a third-year PhD student, presents her findings in a structured manner, beginning with acknowledgments of funding and support from relevant organizations. She introduces her research question regarding the age-related differences in bone structure between osteoarthritic and healthy mice, aiming to identify potential early biomarkers for osteoarthritis.



The presentation highlights the methodologies developed for imaging and segmenting the bones of the mice using advanced software, ensuring the process is reproducible for future research. Lucinda details her results, showing significant differences in bone volume and structure between the two mouse strains throughout different age intervals, hinting at how these differences relate to osteoarthritis onset and progression.



Particular attention is given to the marrow space volume differences between the two strains, which change as the mice age, further reinforcing the importance of assessing not just the bone, but also its surrounding tissues.



The session concludes with acknowledgments from Lucinda, followed by a Q&A segment where she further discusses the implications of her research, especially concerning factorial relationships in bone structure that may influence marrow space volume.

DOI: 10.1302/3114-221100

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