Glutamatergic Signalling is Regulated by Mechanical Loading in a 3-Dimensional Model of Human Stem Cell Derived Osteoytes

Description

In this presentation, Deborah Mason discusses groundbreaking research conducted by Sophie Gilbert on the mechanical loading's effect on human stem cell-derived osteocytes. Osteoarthritis, a prevalent condition affecting 45% of individuals over 65 in the UK and costing billions in healthcare, is linked to abnormal joint loading. The research highlights glutamate, a neurotransmitter that significantly increases in osteoarthritis and rheumatoid arthritis, and its role in joint pain and degeneration. By utilizing 3D cell culture models and RNA sequencing, the study investigates how mechanical loading influences glutamate receptors in osteocytes. Findings reveal that glutamate signaling is regulated by mechanical factors, linking joint mechanics to inflammation and pain pathways. The work aims to elucidate the underlying mechanisms leading to joint degeneration, offering potential therapeutic insights for osteoarthritis.

DOI: 10.1302/3114-221085

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