Description
This presentation features Dr. Elizabeth Darley, a lead clinical doctor at North Bristol NHS Trust specializing in Bone and Joint Infection. She discusses the selection of oral antibiotics for periprosthetic joint infection, highlighting the current debates surrounding antibiotic therapy choices, switch therapy timings, and how to approach treatment in the context of recent MHRA advice regarding quinolones. Dr. Darley shares insights based on her two decades of experience working with orthopedic surgeons in joint infection clinics, emphasizing the importance of antibiotic effectiveness, patient tolerance, and the role of bioavailability in therapy selection.
Key points include:
1. Overview of oral antibiotic options and treatment protocols used at North Bristol NHS.
2. Discussion on critical issues like when to switch to oral therapy, whether to use combination versus monotherapy, and debate around the use of rifampicin especially with metal implants.
3. Identification of common pathogens responsible for joint infections and their sensitivity profiles for antibiotic treatment.
4. Insights into specific antibiotics like quinolones, clindamycin, and doxycycline, discussing their effectiveness, tolerance, and recent contraindications or concerns.
5. The presentation concludes with audience interaction, focusing on questions related to optimal switching times to oral therapy and implications of the latest guidelines.