Direct Ink Writing of Polycaprolactone/Laponite Composite for Bone Implants: 3D Characterisation Using X-ray Micro-computed Tomography

Description

This presentation focuses on the innovative application of Direct Ink Writing (DIW) in the creation of polycaprolactone (PCL) and Laponite composite for bone implants. The key emphasis is on 3D characterization techniques using advanced imaging methods like X-ray and micro-computed tomography (μCT). The speaker, Hongyi Chen, details the methodology of 3D printing, which includes the layer-by-layer deposition of materials, leading to customizable bone implants tailored for specific patient needs.



DIW is highlighted as a promising technique in the biomedical field due to its ability to directly extrude viscous inks at room temperature, maintaining the integrity of sensitive biomaterials and allowing for the incorporation of temperature-sensitive drugs. Printability, a critical factor for successful 3D printing, is defined and assessed, particularly focusing on the shape fidelity of printed products.



The presentation covers the formulation of a printable PCL-Laponite composite, describing the polymer's biocompatibility and the nanoclay's role in promoting cell adhesion and osteogenic differentiation. Results show effective fabrication of a 32-layer porous scaffold and a solid dumbbell-shaped specimen for mechanical testing, with findings on the importance of layer orientations affecting material properties and structural integrity.



Chen concludes with future steps for improvement, addressing the influences of printing parameters on mechanical properties and the potential for generating 3D models from μCT results for further bioactivity analysis.

Specialties