Basic Sciences: X-Linked Dominant

Description

This video from OrthoM8, presented by Harry Benjamin-Laing, explores the concept of X-linked dominant inheritance. It starts by explaining that X-linked dominant conditions can affect both males and females. If a father is affected, it leads to daughters inheriting the affected X chromosome, making all daughters affected while all sons remain unaffected as they inherit the father's Y chromosome. On the other hand, if the father is unaffected and the mother is affected, there is a 50% chance for both sons and daughters to inherit the mutated gene, with males displaying the condition fully, while females show variable expressivity. The video highlights hypophosphatemic rickets as a notable example of an X-linked dominant condition.

Specialties