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- Talk
- 23/06/2023
- CANADA
The Impact and Cost-Analysis of Prophylactic Intranasal Photodynamic Disinfection Therapy (nPDT) and Chlorhexidine Gluconate (CHG) Body Wipes on Surgical Site Infection in Adult Spine Surgery
Description
In this presentation, Eryck Moskven, an orthopedic resident from the University of British Columbia, discusses a research paper on the effectiveness of prophylactic intranasal photodynamic disinfection therapy and chlorhexidine gluconate body wipes in preventing surgical site infections (SSIs) in adult spine surgery. Recognizing that SSIs are serious postoperative complications leading to significant patient morbidity and increased healthcare costs, Eryck highlights the limitations of existing preoperative prophylaxis strategies that mainly rely on nasal mupirocin.
He introduces the novel approach using intranasal photodynamic disinfection therapy, which employs a photoactive dye to induce an antimicrobial effect within the nostrils and has been part of the standard preoperative care at Vancouver General Hospital since 2011. Over 14 years of data from approximately 1,000 patients per year undergoing emergent and elective spine surgeries were analyzed to assess the impact of this therapy on SSI rates and cost savings.
Results indicated a statistically significant reduction in the incidence of SSIs post-implementation of the prophylaxis bundle, with estimated cost savings in the millions. The study highlighted no major adverse events associated with this method, thereby reinforcing its safety and efficacy as a standard of care for spine surgery patients. Eryck concludes by emphasizing the need for future studies to explore variations in microbial organisms and antibiotic resistance, and notes the expanding applicability of this treatment beyond surgical settings.